澹撶府姗� 鏄竴绋皣浣庡姘ｉ珨鎻愬崌鐐洪珮澹撴埃楂旂殑寰炲嫊鐨勬祦楂旀姊�锛屾槸鍒跺喎绯荤当(t菕ng)鐨勫績鑷�銆傚畠寰炲惛姘ｇ鍚稿叆浣庢韩浣庡鐨勫埗鍐峰姂姘ｉ珨锛岄€氶亷闆绘閬嬭綁(zhu菐n)甯跺嫊娲诲灏嶅叾閫�(j矛n)琛屽绺悗锛屽悜鎺掓埃绠℃帓鍑洪珮婧珮澹撶殑鍒跺喎鍔戞埃楂�锛岀偤鍒跺喎寰挵(hu谩n)鎻愪緵鍕曞姏銆�
寰炶€屽鐝�(xi脿n)澹撶府鈫掑喎鍑濓紙鏀剧啽锛夆啋鑶ㄨ劰鈫掕捀鐧�(f膩) ( 鍚哥啽 ) 鐨勫埗鍐峰惊鐠�(hu谩n)
鏂拌仦:鑾掔福寰锋柉铇┖澹撴绌哄姗熷瀷铏熷弮鏁�(sh霉)瑭宠В
鐢�(ch菐n)鍝佺湡姘ｅ瓟鐜囪秺楂橈紝鍖栧(xu茅)鑵愯潟鑸囨帀娓ｇ従(xi脿n)璞¤秺鐐轰簡寤堕暦鐭冲ⅷ闄芥サ鐨勪娇鐢ㄥ＝鍛�锛屽彲浠ョ敤鑻ュ共绋共鎬ф补(濡傛娌广€佷簽楹讳粊娌圭瓑)灏嶅姞宸ュソ鐨勭煶澧ㄩ櫧妤甸€�(j矛n)琛屾蹈娌硅檿鐞�锛屾补娴稿悗鍐嶅湪閬╃暥(d膩ng)婧害涓嬪浐鍖�銆傞€欐ǎ鍙互娓涘皬闆昏В娑插皪闄芥サ姘ｅ瓟鐨勬徊閫�锛屾笡杓曢櫧妤电殑鍖栧(xu茅)鑵愯潟鍜屾帀娓ｇ従(xi脿n)璞�锛屽洜鑰屽欢闀蜂簡闄芥サ鐨勪娇鐢ㄥ＝鍛�锛屼竴鑸彲寤堕暦1/3宸﹀彸銆傛摎(j霉)鏈夐棞(gu膩n)璩囨枡鍫卞皫(d菐o)锛屾湁鐨勭稉(j墨ng)閬庢补娴告棘鐨勯櫧妤典娇鐢ㄥ＝鍛芥彁楂樹簡涓€鍊�銆備絾鏄亷鍒嗙殑娌规蹈鏈冨紩璧烽浕瑙ｆЫ鎿嶄綔鐨勬儭鍖�锛屽皪浜庨珮闆绘祦瀵嗗害鐨勬按閵€闆昏В妲戒娇鐢ㄦ补娴搁櫧妤靛弽鑰屾矑鏈夌泭3.鍖栧伐瑷�(sh猫)鍌欒姹備笉閫忔€х煶澧�銆�
澹撶府姗熷垎鐐烘椿濉炲绺锛岃灪妗垮绺锛岄洟蹇冨绺锛岀洿绶氬绺绛�銆傝姊濅粙绱逛簡澹撶府姗熺殑宸ヤ綔鍘熺悊銆佸垎椤�銆侀厤浠�銆佽(gu墨)鏍�銆侀亱杞�(zhu菐n)瑕佹眰銆佸绺鐨勭敓鐢�(ch菐n)銆佸父瑕嬫晠闅滀互鍙婄挵(hu谩n)淇濊姹�銆侀伕鍨嬪師鍓囥€佸畨瑁濇浠朵互鍙婄櫦(f膩)灞曡定鍕�銆�
澹撶府姗熻鐪嬫垚鏄埗鍐风郴绲�(t菕ng)鐨勫績鑷�锛岃兘琛ㄧ従(xi脿n)澹撶府姗熺壒寰佺殑灏堢敤鍚嶈绋辩偤鈥滆捀姘ｆ车鈥�銆傚绺瀵﹂殯鎵€鎵挎摂(d膩n)鐨勮伔
璨�(z茅)鏄彁鍗囧鍔�锛屽皣鍚告埃澹撳姏鐙€鎱�(t脿i)鎻愰珮鍒版帓姘ｅ鍔涚媭鎱�(t脿i) [2]
銆�
澹撶府姣旀槸澹撳姏宸殑涓€绋妧琛�(sh霉)琛ㄧず鏂瑰紡锛屽叾鍚京鐐洪珮澹撳伌(c猫)澹撳姏闄や互浣庡鍋�(c猫)鐨勫鍔�銆傚绺瘮鐨勮▓绠楀繀闋堥噰鐢ㄥ鍔涘€�銆傜偤浜嗛伩鍏嶄娇澹撶府姣旇▓绠楀€煎嚭鐝�(xi脿n)璨�(f霉)鍊�锛岃▓绠楀鍔涙瘮鏅傚繀闋堥噰鐢ㄥ鍔�锛岃€屼笉鏄〃澹撳姏銆傞噰鐢ㄥ鍔涘€兼墠鑳戒娇澹撶府姣旇▓绠楀€肩偤姝ｅ€�锛岄€欐ǎ鎵嶆湁鎰忕京銆�
鍒跺喎鍜岀┖瑾�(di脿o)琛屾キ(y猫)涓噰鐢ㄧ殑澹撶府姗熸湁5澶ч鍨嬶細寰€寰�(f霉)寮�銆佽灪妗垮紡銆佸洖杞�(zhu菐n)寮�銆佹甫鏃嬪紡鍜岄洟蹇冨紡锛屽叾涓線寰�(f霉)寮忔槸灏忓瀷鍜屼腑鍨嬪晢鐢ㄥ埗鍐风郴绲�(t菕ng)涓噳(y墨ng)鐢ㄥ鐨勪竴绋绺銆傝灪妗垮紡澹撶府姗熶富瑕佺敤浜庡ぇ鍨嬪晢鐢ㄥ拰宸ユキ(y猫)绯荤当(t菕ng)?锛涘墳D(zhu菐n)寮忓绺銆佹甫鏃嬪紡澹撶府姗熶富瑕佺敤浜庡鐢ㄥ拰灏忓閲忓晢鐢ㄧ┖瑾�(di脿o)瑁濈疆锛岄洟蹇冨紡澹撶府姗熷墖寤ｆ硾鐢ㄤ簬澶у瀷妯撳畤鐨勭┖瑾�(di脿o)绯荤当(t菕ng)銆�
鍚勭ó寰€寰�(f霉)寮忓绺涓€鑸牴鎿�(j霉)澹撶府姗熸楂斿舰寮忎互鍙婇﹨(q奴)鍕曟妲�(g貌u)瑷�(sh猫)缃柟寮忓垎椤�銆傛牴鎿�(j霉)娈奸珨褰㈠紡渚嗗垎鏈夐枊鍟熷紡鍜屽皝闁夊紡鍗婂皝闁夊紡澹撶府姗熴€傚皝闁夊紡鏄寚鏁村€嬪绺鍧囪ō(sh猫)缃湪涓€鍊嬫楂斿収(n猫i)銆�
澹撶府姗熸寜鍏跺師鐞嗗彲鍒� [3]
鐐哄绌嶅瀷澹撶府姗熻垏閫熷害鍨嬪绺銆傚绌嶅瀷鍙堝垎鐐猴細寰€寰�(f霉)寮忓绺銆佸洖杞�(zhu菐n)寮忓绺锛涢€熷害鍨嬪绺鍙堝垎鐐猴細杌告祦寮忓绺銆侀洟蹇冨紡澹撶府姗熷拰娣锋祦寮忓绺銆�
濡備粖瀹剁敤鍐扮鍜岀┖瑾�(di脿o)鍣ㄥ绺閮芥槸瀹圭⿳寮�锛屽叾涓張鍙垎鐐哄線寰�(f霉)寮忓拰鏃嬭綁(zhu菐n)寮忋€傚線寰�(f霉)寮忓绺浣跨敤鐨勬槸娲诲銆佹洸鏌�銆侀€ｆ】姗熸(g貌u)鎴栨椿濉炪€佹洸鏌�銆佹粦绠℃妲�(g貌u)锛屾棆杞�(zhu菐n)寮忎娇鐢ㄧ殑澶氭槸婊惧嫊杞�(zhu菐n)瀛愬绺銆傚湪鍟嗙敤绌鸿(di脿o)涓�锛屽張澶氭槸闆㈠績寮忋€佹甫鏃嬪紡銆佽灪妗垮紡銆�
鎸夋噳(y墨ng)鐢ㄨ寖鍦嶅張鍙垎鐐轰綆鑳屽寮�銆佷腑鑳屽寮忋€侀珮鑳屽寮�銆備綆鑳屽寮� ( 钂哥櫦(f膩)婧害 -35 锝� -15 鈩� ) 锛屼竴鑸敤浜庡鐢ㄩ浕鍐扮銆侀鍝佸喎鍑嶇绛夈€備腑鑳屽寮� ( 钂哥櫦(f膩)婧害 -20 锝� 0 鈩� ) 锛屼竴鑸敤浜庡喎椋叉煖銆佺墰濂跺喎钘忕绛�銆傞珮鑳屽寮� ( 钂哥櫦(f膩)婧害 -5 锝� 15 鈩� ) 锛屼竴鑸敤浜庢埧闁撶┖姘ｈ(di脿o)绡€(ji茅)鍣�銆侀櫎婵曟銆佺啽娉电瓑銆�
宸ヤ綔鍘熺悊
鐢ㄥ湪绌哄姗熶笂闈� 涓昏鏄締瑾�(di脿o)绡€(ji茅)绌哄姗熺殑璧峰仠鐙€鎱�(t脿i),閫氶亷瑾�(di脿o)绡€(ji茅)鍎叉埃缃愬収(n猫i)鐨勫鍔涗締璁撶┖澹撴鍋滄浼戞伅,灏嶆鍣ㄦ湁淇濋(y菐ng)浣滅敤.鍦ㄧ┖澹撴宸ュ粻瑾�(di脿o)瑭︾殑鏅傚€�, 鏍规摎(j霉)瀹㈡埗闇€瑕佽(di脿o)绡€(ji茅)鍒板鍔�,鐒跺悗瑷�(sh猫)瀹氫竴鍊嬪宸�.渚嬪,澹撶府姗熼枊濮� 鍟熷嫊,鍚戝劜姘ｇ綈 鎵撴埃,鍒板鍔�10kg鐨勬檪鍊�,绌哄姗熷仠姗熸垨鑰呭嵏杓�,鐣�(d膩ng)澹撳姏鍒�7kg鐨勬檪鍊欑┖澹撴鍙堥枊濮嬪暉鍕�,姝ら枔鏈変竴鍊嬪鍔涘樊,閫欏€嬮亷绋� 灏卞彲浠ヨ畵澹撶府姗熶紤鎭竴涓�,閬�(d谩)鍒颁繚璀�(h霉)绌哄姗熺殑浣滅敤 [5]
銆�
鐢遍浕鍕曟鐩存帴椹�(q奴)鍕曞绺锛屼娇鏇茶桓鐢�(ch菐n)鐢熸棆杞�(zhu菐n)閬嬪嫊锛屽付鍕曢€ｆ】浣挎椿濉炵敘(ch菐n)鐢熷線寰�(f霉)閬嬪嫊锛屽紩璧锋埃缂稿绌嶈畩鍖�銆傜敱鏂兼埃缂稿収(n猫i)澹撳姏鐨勮畩鍖�锛岄€氶亷 閫�(j矛n)姘ｉ枼 浣跨┖姘ｇ稉(j墨ng)閬庣┖姘ｆ烤娓呭櫒(娑堣伈鍣�)閫�(j矛n)鍏ユ埃缂�锛屽湪澹撶府琛岀▼涓紝鐢辨柤姘ｇ几瀹� 绌嶇殑绺皬锛屽绺┖姘ｇ稉(j墨ng)閬� 鎺掓埃闁ョ殑浣滅敤 锛岀稉(j墨ng)鎺掓埃绠�锛屽柈鍚戦枼(姝㈠洖闁�)閫�(j矛n)鍏ュ劜姘ｇ綈锛岀暥(d膩ng)鎺掓埃澹撳姏閬�(d谩)鍒伴瀹氬鍔� 0.7MPa鏅傜敱澹撳姏闁嬮棞(gu膩n)鎺у埗鑰岃嚜鍕曞仠姗�銆傜暥(d膩ng)鍎叉埃缃愬鍔涢檷鑷�0.5--0.6MPa鏅傚鍔涢枊闂�(gu膩n)鑷嫊鑱�(li谩n)鎺ュ暉鍕�銆�
闁嬮棞(gu膩n)绲�(ji茅)妲�(g貌u)
灏嶄簬涓嶅悓鐨勬韩搴︽脯閲忚寖鍦�锛屾噳(y墨ng)閬� 鐢ㄧ祼(ji茅)妲�(g貌u)涓嶅悓鐨勬韩搴﹂枊闂�(gu膩n)锛屽湪0鈩冿綖100鈩冪殑婧害鑼冨湇鍏�(n猫i)锛岄€氬父閲囩敤鍥洪珨鑶ㄨ劰寮忕殑婧害闁嬮棞(gu膩n)锛屽湪100鈩冿綖250鈩冪殑婧害 鑼冨湇鍏�(n猫i)锛屽ぇ澶氶噰鐢ㄦ埃楂旇啫鑴瑰紡婧害闁嬮棞(gu膩n)锛屽皪浜�250鈩冧互涓婄殑婧害鑼冨湇锛屽墖鍙兘閲囩敤鐔遍浕鍋� 鎴栫啽闆婚樆婧害瑷�锛岀稉(j墨ng)閬� 娓噺璁婇€佸櫒杞�(zhu菐n)鎻涚偤妯℃摤閲忛浕淇¤櫉锛屽啀灏囬浕淇¤櫉杞�(zhu菐n)鎻涚偤闁嬮棞(gu膩n)閲忎俊铏� [6]
銆�
鍥洪珨鑶ㄨ劰寮忔韩搴﹂枊闂�(gu膩n)鐨勫伐浣滃師鐞嗘槸锛屽埄鐢ㄤ笉鍚屽浐楂斿彈鐔卞悗闀峰害璁婂寲鐨勫樊鍒ヨ€岀敘(ch菐n)鐢熶綅绉�锛屽緸鑰屼娇瑙搁粸鍕曚綔锛岃几鍑烘韩搴︾殑闁嬮棞(gu膩n)閲� 淇¤櫉銆備緥濡�锛屾湁涓€绋韩搴﹂枊 闂�(gu膩n)鏄敤闆欓噾灞墖(榛冮妳鐗囩枈鍦ㄩ姦閶肩墖涓�)妲�(g貌u)鎴愮殑锛岀敱浜庨粌閵� 鐗囩殑绶� 鑶ㄨ劰绯绘暩(sh霉) 杓冮姦閶肩墖澶�锛屽湪鍙楃啽 鍚�锛岄洐閲戝爆鐗囧氨鏈冪櫦(f膩)鐢熷綆鏇层€傜暥(d膩ng)閬�(d谩)鍒拌(gu墨)瀹氭韩搴︽檪闆欓噾灞墖鑷敱绔�(婧害闁嬮棞(gu膩n)鐨勫嫊瑙搁粸銆曠敘(ch菐n)鐢熻冻 澶犵殑浣嶇Щ锛岃垏鍥哄畾鐨勯潨瑙搁粸鏂烽枊锛岄€佸嚭闁嬮棞(gu膩n)閲忎俊铏�銆�
姘ｉ珨鑶ㄨ劰寮忔韩搴﹂枊闂�(gu膩n) 鏄寜姘ｉ珨澹撳姏寮忔韩搴﹁▓鐨勫師鐞嗗伐浣滅殑銆� 瀹冩湁涓€鍊嬫脯婧寘锛屽収(n猫i)鍏呮爱姘�锛岄€氶亷瀵嗗皝姣涚窗(x矛)绠℃帴鍒板鍔涢枊闂�(gu膩n) 鐨勬脯閲忓厓浠朵腑銆傜暥(d膩ng) 琚脯婧害 閬�(d谩)鍒拌(gu墨)瀹氬€兼檪锛屾韩鍖呭収(n猫i)鐨勫厖姘ｅ鍔涗娇澹撳姏闁嬮棞(gu膩n)鍕曚綔銆�
鏂拌仦:鑾掔福寰锋柉铇┖澹撴绌哄姗熷瀷铏熷弮鏁�(sh霉)瑭宠В鐢�(ch菐n)鍝佸湪閫欑ó姒傜巼鎰忕京涓婄殑鐒¤弻淇濊瓑骞朵笉鑳戒緷璩翠簬绲傜敘(ch菐n)鍝佺殑鐒¤弻妾㈤锛岃€屾槸鍙栨焙浜庣敓鐢�(ch菐n)閬庣▼涓噰鐢ㄥ悎鏍肩殑宸ヨ棟銆佸毚(y谩n)鏍肩殑GMP绠＄悊鍜岃壇濂界殑璩�(zh矛)閲忎繚璀夐珨绯�銆傞€欐剰鍛宠憲鎵圭敓鐢�(ch菐n)閬庣▼鐨勭洠(ji膩n)鎺у皣姣旀壒鐒¤弻瑭﹂绲�(ji茅)鏋滄洿鑳藉弽鏄犵敘(ch菐n)鍝佺殑鐒¤弻淇濊瓑姘村钩銆傜敘(ch菐n)鍝佺殑鐒¤弻淇濊瓑鑸囧墠鐢�(ch菐n)鍝佽姹℃煋鐨勭▼搴﹀強姹℃煋鑿岀殑鐗规€х浉闂�(gu膩n)銆傛噳(y墨ng)鍤�(y谩n)鏍肩洠(ji膩n)鎺ц鍝佸墠鐨勫井鐢熺墿姹℃煋姘村钩鍙婃薄鏌撹弻鐨勮€愬彈鎬�锛屽苟鍦ㄧ敓鐢�(ch菐n)鐨勫悇鍊嬬挵(hu谩n)绡€(ji茅)閲囧彇鍚勭ó鎺柦闄嶄綆姹℃煋锛岀⒑淇濆井鐢熺墿姹℃煋鎺у埗鍦ㄨ(gu墨)瀹氱殑闄愬害鍏�(n猫i)銆�
